Revisiting ampa receptors as an antiepileptic drug target. The other receptors are the ampa and kainate receptors. Biological psychology is available from oxford university press. Glutamate receptor nmda receptor ion channel channel blocker pharmacology. The nmda receptor is one of three types of ionotropic glutamate receptors. What is the difference between nmda and ampa receptors. Structure, function, and pharmacology of nmda receptor channels. Structure, function, and pharmacology of nmda receptor. Ampa receptors are the most abundant ionotropic glutamate receptors in the mammalian brain. Effect of oxygen and glucose deprivation on nmda receptor. The ampa receptors present a unique characteristic in the mechanisms of subunit regulation during ltp longterm potentiation and ltd longterm depression, which are involved in the. However, one of the most devastating effects of alcohol leads to brain shrinkage, loss of nerve cells at specific regions through a mechanism involving excitotoxicity, oxidative stress. Nmda receptor antagonists that would block excitotoxic nmda receptor activation, without interfering with nmda receptor function needed for normal synaptic transmission and plasticity.
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